A distributed infrastructure for life-science information - Building a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine, agriculture, bioindustries and society
From September 2015, ‘ELIXIR-EXCELERATE’ is facilitating the integration of Europe’s bioinformatics resources, supporting all sectors of life-science R&D. It will deliver excellence to ELIXIR’s users by fast-tracking the development and deployment of essential data services.
Coordinator: Niklas Bloomberg
Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes
Microbial eukariotes cover the widest phylogenetic diversity in the eukaryotic tree of life and are essential components of all Earth’s ecosystems. Paradoxically, they remain large unknown, hiding a wealth of genes and genomes that are key to understand the ecology and evolution of microbial...
Coordinator: Ramon Massana
Determining the three-dimensional structure of genomes and genomic domains
Over the last decade, and especially after the advent of fluorescent in situ hybridization imaging and Chromosome Conformation Capture methods, the availability of experimental data on genome three-dimensional (3D) organization has dramatically increased. We now have access to unprecedented details...
Coordinator: Marc A. Marti-Renom
Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer
Buruli ulcer (BU) is a neglected emerging infectious disease caused by Mycobacterium ulcerans. BU has become the third most prevalent mycobacteriosis worldwide, after tuberculosis and leprosy. Limited knowledge of the disease and the fact that it affects mainly poor rural communities contribute to...
Coordinator: Jorge Pedrosa
Boosting the Infrastructure for Omics Technologies
All omics technologies produce large volumes of data that require very specific processing and preparation for downstream interpretation. Going forward the major problems for all omics technologies is to provide efficient, robust and standardized methods for primary data handling and analysis. It...
Coordinator: Ivo Gut
Exploration of non-random Somatic Mutations in Cancer Genomes
Cancer is a disease of the genome. Somatic mutations accumulate on top of the germline genome from many exogenous insults that we are constantly exposed to. If mutations are not removed or repaired they can result in progression to cancer disease. It is know that many of the insults we are exposed...
Coordinator: Ivo Gut