The Genomic study of Chronic Lymphocytic Leukaemia
The International Cancer Genome Consortium is an international effort to establish a comprehensive descriptionof genomic, transcriptomic and epigenomic changes in50 different tumor types and/or subtypes which are of clinical and societal importance across the globe. Spain’scontribution to the ICGC...
Coordinator: Elias Campo & Carlos López-Otín
Elucidating structural variation in primate genomes
The PRIMATE project aims to discover the extent of genome structural polymorphism within the great ape species by generating next-generation sequencing datasets at high coverage from multiple individuals of diverse species and subspecies, characterizing structural variants and validating them...
Coordinator: Tomàs Marquès-Bonet
Development of new statistical tools for improving the detection of population substructure at individual level with applications in humans
Detecting population substructure in Homo sapiens from the genetic diversity of the species is cumbersome given its evolutionary history and recent origin. Nevertheless, population substructure represents a serious threat when conducting GWAS and properly identifying its signature is essential for...
Coordinator: Oscar Lao
Exploration of non-random Somatic Mutations in Cancer Genomes
Cancer is a disease of the genome. Somatic mutations accumulate on top of the germline genome from many exogenous insults that we are constantly exposed to. If mutations are not removed or repaired they can result in progression to cancer disease. It is know that many of the insults we are exposed...
Coordinator: Ivo Gut
Boosting the Infrastructure for Omics Technologies
All omics technologies produce large volumes of data that require very specific processing and preparation for downstream interpretation. Going forward the major problems for all omics technologies is to provide efficient, robust and standardized methods for primary data handling and analysis. It...
Coordinator: Ivo Gut
Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer
Buruli ulcer (BU) is a neglected emerging infectious disease caused by Mycobacterium ulcerans. BU has become the third most prevalent mycobacteriosis worldwide, after tuberculosis and leprosy. Limited knowledge of the disease and the fact that it affects mainly poor rural communities contribute to...
Coordinator: Jorge Pedrosa

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