The Structural Genomics group interest is the molecular mechanisms that regulate cell fate.
The genome undergoes several layers of compaction in order to be accommodated into the nucleus. Almost nothing is known about how such folding is controlled, but recent discoveries clearly indicate that this folding and compaction is non-random. There is also a growing appreciation that disruption in normal chromosomal organization through long-range contacts is a source of human disease including cancer. Therefore, it is necessary to characterize this level of organization of the nucleus.
To study such mechanisms, the Structural Genomics group employs the laws of physics and the rules of evolution to develop and apply computational methods for predicting the three-dimensional organization of the genome and the non-coding RNA molecules that act in its regulation. To do so, we develop the RNA and Chromatin modules of the Integrative Modeling Platform
Find more information at http://marciuslab.org