Development of new statistical tools for improving the detection of population substructure at individual level with applications in humans
Detecting population substructure in Homo sapiens from the genetic diversity of the species is cumbersome given its evolutionary history and recent origin. Nevertheless, population substructure represents a serious threat when conducting GWAS and properly identifying its signature is essential for...
Coordinator: Oscar Lao
Multi-scale complex genomics
The European three-dimensional (3D) genomics project entitled “Multi-scale complex genomics” (MuG) is coordinated by Dr. Modesto Orozco, at the Institute for Research in Biomedicine (IRB Barcelona) and it will be conducted over three years with a budget of 3 million euros. The goal is to...
Coordinator: Modesto Orozco
Breast CAncer STratification - Understanding the determinants of risk and prognosis of molecular breast cancer subtypes. The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develo
The B-CAST project (Breast CAncer STratification) is coordinated by the Netherlands Cancer Institute Antoni Van Leeuwenhoek and it will be conducted over five years (until September 2020). Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental...
Coordinator: Marjanka Schmidt
Dynamics of human genome architecture in stable and transient gene expression changes
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output...
Coordinator: Miguel Beato
Biobanking and Biomolecular Research Inffrastructure - Large Prospective Cohorts
In response to a specific infrastructure call of the FP7 of the European Commission, BBMRI-LPC (Biobanking and Biomolecular Resources Research Infrastructure – Large Prospective Cohorts) a European-wide project involving 30 partners from 17...
Coordinator: Markus Perola
Inflammatory Bowel Disease CHARACTERization
IBD-CHARACTER is a a collaborative effort to advance understanding of the inflammatory bowel diseases Ulcerative Colitis andCrohn's Disease and to increase diagnostic precision in detection of the diseases in their early manifestation. We will utilizethe largest collection of samples so far...
Coordinator: Jack Satsangi